Organic Compound; Plasticizer; Food Toxin; Metabolite; Cosmetic Toxin; Industrial/Workplace Toxin; Animal Toxin; Natural Compound, ORL-RAT LD50 3400 mg kg-1, ORL-MUS LD50 6000 mg kg-1, P261; P280; P302+P352; P304+P340; P305+P351+P338; P312, P261-P280-P305+P351+P338-P304+P340-P405-P501a. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH 2) 8 (CO 2 H) 2.It is a white flake or powdered solid. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. However works on polyesters of sebacic acid are rare. Diesters of sebacic acid find various applications as plasticizers, solvents and lubricants. The product is described as non-hazardous, though in its powdered form it can be prone to flash ignition (a typical risk in handling fine organic powders). It has a role as a human metabolite and a plant metabolite. [3], Sebum is a secretion by skin sebaceous glands. 2. One of the largest uses of Sebacic Acid is in the manufacture of Nylon 6-10. Sebacic acid is produced from castor oil by cleavage of ricinoleic acid, which is obtained from castor oil. text.skipToContent text.skipToNavigation. 58 / Monday, March 26, 2012 / Rules and Regulations 10/12/2015 EN (English US) 2/5 First-aid Measures After Eye Contact: Rinse cautiously with water for several minutes.Remove contact lenses, if present and It is resolved in ethanol, ether and soluble slightly in water. Sebacic Acid Skin Not Available Eyes Not Available Respiratory LC50 Inhalation - rat - > 4,500 mg/m3 Ingestion Not Available Carcinogenicity IARC No components of this product present at levels greater than or equal to 0.1% Sebacic Acid PGS has a linear degradation profile via surface erosion, is completely bioresorbable, and its macroporous structure is well suited for cellular infiltration, paracrine signaling, and neotissue formation.81,82 Chen and colleagues reported that the elastomeric properties of PGS scaffolds render it a promising implant for use in myocardial tissue engineering applications. Degree of solubility in water: 1 g/l 20 °C: Solubility (very soluble in) Alcohol: CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:41865, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, 295 deg C / 100 mm (400.5825 °C / 760 mmHg), 295 °C / 100 mm (400.5825 °C / 760 mmHg), 294.5 °C / 100 mmHg (399.9979 °C / 760 mmHg). Solubilities of sebacic acid in binary ethanol + water solvent mixtures were measured by the dynamic method using a laser monitoring observation technique at a temperature range from (288 to 352) K. The mole fraction of ethanol in the solvent mixtures ranges from 0 to 1. Human neutrophils can convert sebacic acid to its 5-oxo analog, i.e.5-oxo-6E,8Z-octadecaenoic acid (5-oxo-ODE). Registrant / Supplier Registered Updated 3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium 2016 [Confidential] ARKEMA CASDA 420 rue d'Estienne d'Orves 92700 Colombes France 2010 ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France Abstract. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII) are a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. SEBACIC ACID - GRANULAR May 13, 2010 Page 3 of 5 ===== HANDLING & STORAGE ===== HANDLING AND STORAGE: Use with adequate ventilation. Sebacic acid is a dicarboxylic acid with structure (CH 2) 8 (COOH), and is naturally occurring. Octanol is a byproduct. It is a white flake or powdered solid. Sebacic Acid Safety Data Sheet According to Federal Register / Vol. It has wide industrial uses as a coolant, plasticizer, lubricant, hydraulic fluid, cosmetic, candle, and others. Can react with active metals to form gaseous hydrogen and a metal salt. The solubility in 95% ethanol (100ml) is 11.7g. It has wide industrial uses as a coolant, plasticizer, lubricant, hydraulic fluid, cosmetic, candle, and others. It is a white flake or powdered solid. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. Regd. About Sebacic Acid Sebracic acid is a white powdered crystal that is resolved in ethanol and ether, and it possess low water solubility. Mobility Will likely be mobile in the environment due to its water solubility. Solubility in water: 0.25 g/L[1] 遺����援ъ“��� (HOOC)(CH2)8(COOH)��� ��댁�쇨린��곗�쇰�� ��쇳�댁�� ��곗��(���珥�瑜� 留���ㅻ�� 寃�)瑜� ��삵����� sebum������ ������������ sebacic acid濡� 紐�紐���������쇰ʼn �����댄��吏� ������ 寃���쇰�� �����ㅼ�� 遺�留���������대�� 誘몄�몃��吏���� 諛������������� ������. 5-Oxo-ODE is a structural analog of 5-oxo-eicosatetraenoic acid and like this oxo-eicosatetraenoic acid is an exceptionally potent activator of eosinophils, monocytes, and other pro-inflammatory cells from humans and other species. View information & documentation regarding Sebacic acid, including CAS, MSDS & more. It is a conjugate acid of a sebacate (2-) and a sebacate. To detect the synergistic effect, solubilities of sebacic acid in 14.35 %, 36.97 %, 79.81 %, and 90.00 % mole fraction ethanol aqueous solution were determined to supplement our previous report. SEBACIC ACID: ICSC: 1685: 1,10-Decanedioic acid 1,8-Octanedicarboxylic acid Decanedioic acid: April 2008 Property Value Probability; Human Intestinal Absorption + 0.5731: Blood Brain Barrier + 0.7397: Caco-2 permeable-0.6412: P-glycoprotein substrate Solubility Slightly soluble in water. We also Provide Trading Suppliers & Manufacture for 17265-14-4 SEBACIC ACID ��� Sebacic acid is a normal urinary acid. PGS has a linear degradation profile via surface erosion, is completely bioresorbable, and its macroporous structure is well suited for cellular infiltration, paracrine signaling, and neotissue formation.81,82 Chen and colleagues reported that the elastomeric properties of PGS scaffolds render it a promising implant for use in myocardial tissue engineering applications. CAS 111-20-6, EC Number 203-845-5, chemical formula HOOC(CH���)���COOH. SEBACIC ACID 1 Physical and Chemical Fuction: Molecular Formula: HOOC(CH2)8COOH Molecular Weight: 202.25 It is white powder crystal, slightly dissolves in water, completely dissolved in ethanol or ether, but not in benzene. May react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Sebacic Acid Safety Data Sheet According to Federal Register / Vol. Sebacic acid is a derivative of castor oil.[2]. 77, No. Slightly soluble in water. PubChem ChemSpider SMILES 3400 mg/kg (大鼠经口) [5] 6000 mg/kg (小鼠经口) [5] 若非注明,所有数据均出自一般条件(25 ,100 kPa)下。 Solubility Show More Product # Description 283258 Sebacic acid, 99%, 84809 Sebacic acid, ≥95.0% (GC), 8.00753 Sebacic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. Approximation models were employed for determining solubility of sebacic acid at elevated temperatures. Sebacic acid for synthesis. Main Use: CAS number. Sebacic acid is a derivative of castor oil. An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. - Find MSDS or SDS, a COA, data sheets and more information. A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, … Stable. In its pure state it is a white flake or powdered crystal. Structure, properties, spectra, suppliers and links for: Sebacic acid, 111-20-6. Sebacic acid (SA) is an aliphatic ten-carbon dicarboxylic acid (1,10-decanedioic acid) with a variety of industrial applications, including the production of plasticizers, lubricants, cosmetics, and plastics. Sigma-Aldrich offers a number of Sebacic acid products. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Contact Supplier High quality Sebacic Acid Disodium Salt Supplier Component log Pow Decanedioic acid 1.5 13. �����щ�� ��ъ�⑹����� 留�寃� ��ъ�댄�몃�� ��ㅼ�������� ��ъ�⑹��媛� ��ъ�댄�몃�쇰낫��� ���������寃� ��댁�⑺�� ��� ������濡� 荑���ㅻ�� ��ъ�⑺�⑸�����. Wash thoroughly after handling. Mobility Will likely be mobile in the environment due to its water solubility. Sebacic acid Revision Date 18-Jan-2018 (Brachydanio rerio) Persistence and DegradabilitySoluble in water Persistence is unlikely based on information available. Decanedioic acid sodium salt TOP1 supplier Cas No: 17265-14-4 USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Avoid contact with skin and eyes. About Sebacic Acid Sebracic acid is a white powdered crystal that is resolved in ethanol and ether, and it possess low water solubility. Compared with short-chain aliphatic acid, sebacic acid is more suitable for the preparation of polyesters, as short-chain aliphatic acids always conduce to intramolecular condensation. SEBACIC ACID reacts exothermically to neutralize bases, both organic and inorganic. Water solubility Solubility in organic solvents / fat solubility Surface tension Flash point Auto flammability Flammability Explosiveness Oxidising properties Oxidation reduction potential Stability in organic solvents and identity of It is suggested that sebacic acid is converted to its 5-oxo analog during, and thereby stimulates pro-inflammatory cells to contribute to the worsening of, various inflammatory skin conditions. Sebacic acid, a 10 carbon containing dicarboxylic acid (DCA), is an important precursor in the production of nylon and polyamides (PAs), primarily PA-4,10 and PA-5,10 (Chung et al. Currently, SA is produced exclusively from alkaline pyrolysis of castor oil. 111-20-6. The solubility of sebacic acid in subcritical water was investigated. Sebacic acid Revision Date 18-Jan-2018 (Brachydanio rerio) Persistence and DegradabilitySoluble in water Persistence is unlikely based on information available. Other identifiers. Bioaccumulation/ AccumulationNo information available. SEBACIC ACID reacts exothermically to neutralize bases, both organic and inorganic. Sebacic Acid is a white flake or powdered crystal. A process for preparing sebacic acid comprising in a first step reacting (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid, and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid. Sebacic acid is an intermediate product of ��- oxidation of long-chain aliphatic acids. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD), also known as glutaric aciduria type II (GAII), a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. Sebacic acid: Overview. 77, No. Sebacic acid (8Cl) Registration dossier . Sublimes slowly at 750 mm Hg when heated to melting point. Registration dossier . CopyCopied, InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14) Sebacic acid is also found in other lipids that coat the skin surface. Sebacic acid: ��ε�� ��������� 1,8 ... Foti, C.; Sammartano, S. Solubility and Activity Coefficients of Acidic and Basic Nonelectrolytes in Aqueous Salt Solutions. An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. Sebacic acid 111-20-6 Sebacic acid 1,3,5-triazine-2,4,6-triamine salt 31970-90-8 Sebacic acid 1,3,5-triazine-2,4,6-triamine salt 94159-18-9 Sebacic acid 2,2',2''-nitrilotriethanol complex 94202-16-1 Sebacic acid 2,2',2 85030-06-4 Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Sebacic acid is a derivative of castor oil. It is a white flake or powdered solid. Combustible. A weak synergistic effect was found for sebacic acid + ethanol + water mixed systems. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Sebacic acid is a normal urinary acid. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH 2) 8 (CO 2 H) 2.It is a white flake or powdered solid. Currently, SA is produced exclusively from alkaline pyrolysis of castor oil. [6], InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14), InChI=1/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14), Except where otherwise noted, data are given for materials in their, Ullmann's Encyclopedia of Industrial Chemistry, "Mammalian Wax Biosynthesis II: Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family", https://en.wikipedia.org/w/index.php?title=Sebacic_acid&oldid=999055436, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 131 to 134.5 °C (267.8 to 274.1 °F; 404.1 to 407.6 K), This page was last edited on 8 January 2021, at 07:53. 1272/2008 [CLP] Extra labelling to displayExtra classification(s) to display In the industrial setting, sebacic acid and its homologues such as azelaic acid can be used as a monomer for nylon 610, plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc. CopyCopied, CXMXRPHRNRROMY-UHFFFAOYSA-N Sebacic Acid. Bioaccumulation/ AccumulationNo information available. 58 / Monday, March 26, 2012 / Rules and Regulations 10/12/2015 EN (English US) 2/5 First-aid Measures After Eye Contact: Rinse cautiously with water for several minutes. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Sebacic Acid. Gujarat India. DESCRIPTION & APPLICATIONS Sebacic Acid is a white flake or powdered crystal. Other Information Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. [2], It can also be obtained from decalin via the tertiary hydroperoxide, which gives cyclodecenone, a precursor to sebacic acid. It is a waxy set of lipids composed of triglycerides (≈41%), wax esters (≈26%), squalene (≈12%), and free fatty acids (≈16%). Material Safety Data Sheet Sebacic acid sc-215843 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Sebacic acid STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. The solubility of sebacic acid was found as 500 g L −1 in the optimum conditions at 400 K temperature, 4 min dynamic time and 28 min static time. Sebacic acid is a derivative of castor oil. Lookchem Provide Cas No.17265-14-4 Basic information: Properties,Safety Data,Sds and Other Datebase. Sebazinsaeure. Disposal considerations Response surface methodology was used to study the combined effects of the different parameters such as temperature, static and dynamic time to optimize the process conditions for the maximum solubility of sebacic acid. The castor oil is treated with caustic soda at high temperature, e.g. 250°C, so that saponification, leading to the formation of ricinoleic acid; is followed by a reaction giving sebacic acid and octan-2-ol Figure 18.5. 1. SEBACIC ACID FOR SYNTHESIS Safety Data Sheet www.lobachemie.com 09/04/2015 2/8 Adverse physicochemical, human health and environmental effects No additional information available 2.2. Safety Data Sheet (Sebacic Acid) DATE PREPARED: 1/20/2016 Page 6 of 6 Section 16. - Find MSDS or SDS, a COA, data sheets and more information. Sebacic Acid was named from the Latin sebaceus (tallow candle) or … Sebacic acid is an alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. Catalogue Number Availability Packaging Qty/Pack Price Sebacic acid (CAS NO.111-20-6) is a low toxic substance, with flammability, burning will produce toxic fumes, so it should be stored in cool and dry environment, dry powder, foam, sand, carbon dioxide, water mist can be used if Office : Sebacic India Limited 301 World Trade Center, Sayajigunj, Vadodara - 390 005. Sebacic acid (SA) is an aliphatic ten-carbon dicarboxylic acid (1,10-decanedioic acid) with a variety of industrial applications, including the production of plasticizers, lubricants, cosmetics, and plastics. Other names. and has antitumor activity. 2. The castor oil is treated with caustic soda at high temperature, for example 250 C, so that saponification, leading to the formation of ricinoleic acid, is followed by a reaction giving sebacic acid and octan-2-ol: Sebacic Acid Skin Not Available Eyes Not Available Respiratory LC50 Inhalation - rat - > 4,500 mg/m3 Ingestion Not Available Carcinogenicity IARC No components of this product present at levels greater than or equal to 0.1% is identified as probable, possible or ��� This action is mediated by the OXER1 receptor on these cells. Label elements Labelling according to Regulation (EC) No. : Rinse cautiously with water for several minutes. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Sebacic Acid was named from the Latin sebaceus (tallow candle) or sebum (tallow) in reference to its use in the manufacture of candles. CAS 111-20-6, EC Number 203-845-5, chemical formula HOOC(CH₂)₈COOH. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. Sebacic acid is a derivative of castor oil. Solubilities of sebacic acid in binary ethanol + water solvent mixtures were measured by the dynamic method using a laser monitoring observation technique at a … [4,9] Poly( Ethylene Sebacic acid for synthesis. Applications Sebacic acid is used as a monomer for nylon 610, plasticizers, lubricants, hydraulic fluids, cosmetics and candles. Sebacic acid Description In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD), also known as glutaric aciduria type II (GAII), a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. [4][5] Included in the free fatty acid secretions in sebum are polyunsaturated fatty acids of which sebacic acid is a major component. Solubility results of sebacic acid were observed to be highly correlated with quadratic model according to analysis of variance. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. C(CCCCC(=O)O)CCCC(=O)O CopyCopied, CSID:5004, http://www.chemspider.com/Chemical-Structure.5004.html (accessed 23:35, Jan 8, 2021) Telaglenastat (CB-839) New Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Display Name: Sebacic acid EC Number: 203-845-5 EC Name: Sebacic acid CAS Number: 111-20-6 Molecular formula: C10H18O4 IUPAC Name: decanedioic acid Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. Sebacic acid and hexamethylene diisocyanate react through condensation polymerization to produce Nylon 6-10. Sebacic acid (8CI) Registration dossier . 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